Some tools that you can use (non-exhaustive)
RefFreeEWAS Houseman et al, 2016, BMC bioinformatics, PMID 27358049 [NMF]
MeDeCom Lutsik et al, 2017, Genome Biology, PMID 28340624 [NMF]
EDec Onuchic et al, 2017, Cell reports, PMID 27851969 [NMF]
DeconICA Czerwinska et al. [ICA]
Decoder Peng et al 2019, Nature communications. [NMF + NNLS]
deconf Repsilber et al., 2010, BMC bioinformatics. [Random Forest + NNLS]
Deblender Dimitrakopoulou et al 2018, Bioinformatics. [NMF](MATLAB)
WISP Blum et al 2019, Nature communications. [NNLS]
DSA Zhong et al., 2013, BMC bioinformatics. [NNLS]
DeconvSeq Du et al 2019 Bioinformatics. [GLM]
LRCDE Glass and Dozmorov, 2016, BMC bioinformatics. [LM]
MMAD Liebner et al 2014, Bioinformatics. [Maximum likelihood/ Conjugate gradient](MATLAB)
DeconRNASeq Gong and Szustakowski, 2013, Bioinformatics. [NNLS]
MuSic Wang et al 2019, Nature communications. [NNLS]
CellMix Gaujoux and Seoighe, 2013, Bioinformatics. [including DSA and deconf, NMF]